Loss of Heterozygosity at llplS in Malignant Glioma1
نویسندگان
چکیده
Deletions of loci on chromosome lip have been found frequently in several malignant tumors including gliomas, suggesting the presence of tumor suppressor genes. We analyzed 38 gliomas [26 malignant gliomas (grades III and IV) and 12 less malignant gliomas (grades I and II)] for loss of heterozygosity using microsatellite sequences on lip as polymor phic markers. Loss of heterozygosity was found in 8 of 26 malignant gliomas (31%) but not in the less malignant gliomas. In the region with loss of heterozygosity, loci on Ilpl5.5-pter were commonly deleted. Our results suggest that a putative tumor suppressor gene involved in malig nant progression of gliomas is located in an approximately 21-cM region on llplS.S-pter.
منابع مشابه
Metastasis Breast Tumors Is Associated with Poor Survival after Loss of Heterozygosity for Chromosome 11 in Primary Human
A common feature of the malignant progression of human tumors is loss of heterozygosity (LOH) for various regions of their genomes. Such events encompassing chromosomes llplS and Hq23 are frequent in human breast tumors. Here, we have analyzed genetic and clinical char acteristics of a series of primary breast tumors in order to determine: (a) a more finely mapped estimate of the involved regio...
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